The International Cardiac Arrest Registry

Antibiotic prophylaxis associated with less pneumonia and sepsis in TTM after cardiac arrest

Using the Northern Hypothermia Network data set (n=1240), David Gagnon PharmD showed less pneumonia (12.6% vs. 54.9%, p < 0.001) and less sepsis (1.2 vs. 5.7%, p < 0.001) compared to no-PRO patients. ICU length of stay (98 vs. 100 h, p = 0.2) and incidence of a good functional outcome (41.1 vs. 36.6%, p = 0.19) were similar between groups. Backwards stepwise logistic regression demonstrated prophylactic antibiotics were independently associated with a lower incidence of pneumonia (OR 0.09, 95% 0.06-0.14, p < 0.001) and a similar incidence of good functional outcome. Dr. Gagnon is currently preparing a prospective trial of antimicrobial prophylaxis during TTM after cardiac arrest.  read more at: Resuscitation 2015;92:154-9.